Publications

Lindsey S. Marmont, Anna K. Orta, Becca W.A. Baileeves, David Sychantha, Ana Fernández Galliano, Yancheng E. Li, Neil G. Greene, Robin A. Corey, Phillip J. Stansfeld, William M. Clemons Jr, Thomas G. Bernhardt. “Synthesis of lipid-;inked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa” (2024) Nature Microbiology 9, 763-775
https://doi.org/10.1038/s41564-024-01603-2

A. Karen Orta*, Nadia Riera*, Yancheng E. Li, Shiho Tanaka, Hyun Gi Yun, Lada Klaic, William M.Clemons, Jr. “The mechanism of the phage-encoded protein antibiotic from ΦX174.” (2023) Science v381 n6654 http://doi.org/10.1126/science.adg9091
PDBID 8G01 8G02; Free article download link; Perspective by Balbach & Stubbs; Caltech News feature

52 Black Scientists “Juneteenth in STEMM and the barriers to equitable science.” (2023) Cell v186 n12 pp2510-2517.
https://doi.org/10.1016/j.cell.2023.05.016

Ailiena Maggiolo, Shivansh Mahajan, Douglas C. Rees, William M. Clemons. “Intradimeric Walker A ATPases: Conserved features of a functionally diverse family.” (2023) Journal of Molecular Biology v435 n11
https://doi.org/10.1016/j.jmb.2023.167965

Alexandra N. Barlow*, M. S. Manu*, Shyam M. Saladi, Paul T. Tarr, Yashpal Yadav, Aye M. M. Thinn, Yun Zhu, Arthur D. Laganowsky, William M. Clemons, Jr., Sureshkumar Ramasamy, “Structures of Get3d reveal a distinct architecture associated with the emergence of photosynthesis” (2023) Journal of Biological Chemistry
https://doi.org/10.1016/j.jbc.2023.104752 PDBID 8ELF 8EGK

Gail A. Robertson, William M. Clemons Jr., Theanne N. Griffith. “Being Black in Biophysics.” (2023) Biophysical Journal
https://doi.org/10.1016/j.bpj.2023.03.025

Michelle Y. Fry, Vladimíra Najdrová, Ailiena O. Maggiolo, Shyam M. Saladi, Pavel Doležal, William M. Clemons, Jr., “Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3” (2022) Nature Structural & Molecular Biology
https://doi.org/10.1038/s41594-022-00798-4 PDBID 7SPZ 7SPY 7SQ0 EMD 25374 25373 25375

Michelle Y. Fry*, Shyam M. Saladi*, Alexandre Cunha, William M. Clemons, Jr., “Sequence‐based features that are determinant for tail‐anchored membrane protein sorting in eukaryotes” (2021) Traffic
https://doi.org/10.1111/tra.12809

Michelle Y. Fry*, Shyam M. Saladi*, William M. Clemons, Jr., “The STI1‐domain is a flexible alpha‐helical fold with a hydrophobic groove” (2021) Protein Science
https://doi.org/10.1002/pro.4049

Ku-Feng Lin, Michelle Y. Fry*, Shyam M. Saladi*, William M. Clemons, Jr., “Molecular basis of tail-anchored integral membrane protein recognition by the cochaperone Sgt2” (2021) Journal of Biological Chemistry Vol 296, 100441
https://doi.org/10.1016/j.jbc.2021.100441

Shyam M. Saladi, Ailiena O. Maggiolo, Kate Radford, William M. Clemons, Jr., “Structural Biologists, Let's Mind Our Colors” (2020) bioRxiv
https://doi.org/10.1101/2020.09.22.308593

Hyun Gi Yun, Kyoung-soon Jang, Shiho Tanaka, William M. Clemons, Jr., “The structure of the UDP-Glc/GlcNAc 4-epimerase from the human pathogen Campylobacter jejuni” (2020) bioRxiv https://doi.org/10.1101/2020.09.22.308395 PDBID 7K3P

Katsuhiko Mitachi, Rita G. Kansal, Kirk E. Hevener, Cody D. Gillman, Syed M. Hussain, Hyun Gi Yun, Gustavo A. Miranda-Carboni, Evan S. Glazer, William M. Clemons, Jr., and Michio Kurosu, “DPAGT1 Inhibitors of Capuramycin Analogues and Their Antimigratory Activities of Solid Tumors” (2020) Journal of Medicinal Chemistry Vol 63 No 19 pp 10855-78
https://doi.osrg/10.1021/acs.jmedchem.0c00545

Katsuhiko Mitachi, Shou M. Kurosu, Shakiba Eslamimehr, Maddie R. Lemieux, Yoshimasa Ishizaki, William M. Clemons, Jr., Michio Kurosu, “Semisynthesis of an Anticancer DPAGT1 Inhibitor from a Muraymycin Biosynthetic Intermediate” (2019) Organic Letters Vol 21 No 4 pp 876-9
https://pubs.acs.org/doi/full/10.1021/acs.orglett.8b03716

Katsuhiko Mitachi, Hyun Gi Yun, Sara M. Kurosu, Shakiba Eslamimehr, Maddie R. Lemieux, Lada Klaić, William M. Clemons, Jr., Michio Kurosu, “Novel FR-900493 Analogues That Inhibit the Outgrowth of Clostridium difficile Spores” (2018) ACS Omega Vol 3 No 2 pp 1726–39 https://doi.org/10.1021/acsomega.7b01740

Shyam M. Saladi, Nauman Javed, Axel Müller, William M. Clemons, Jr., “Decoding sequence-level information to predict membrane protein expression” (2018) Journal of Biological Chemistry Vol 293 No 13 pp 4913-27
https://doi.org/10.1074/jbc.RA117.001052

Michiel J.M. Niesen*, Stephen S. Marshall*, Thomas F. Miller III, William M. Clemons, Jr., “Improving membrane protein expression by optimizing integration efficiency” (2017) Journal of Biological Chemistry Vol 292 No 47 pp 19537-45 https://doi.org/10.1074/jbc.M117.813469
Highlight by J.C. Gumbart

Jee-Young Mock, Yue Xu, Yihong Ye, William M. Clemons, Jr., “The structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC3” (2017) Proceedings of the National Academy of Sciences Vol 114 No 44 pp 11679-84 https://doi.org/10.1073/pnas.1702940114 PDBID 6AU8

Stephen S. Marshall*, Michiel J.M. Niesen*, Axel Mueller, Katrin Tiemann, Shyam M. Saladi, Rachel P. Galimidi, Bin Zhang, William M. Clemons, Jr., Thomas F. Miller III “A Link between Integral Membrane Protein Expression and Simulated Integration Efficiency” (2016) Cell Reports. Vol 16 No 8 pp 2169-77 https://doi.org/10.1016/j.celrep.2016.07.042

Harry B. Gristick, Michael E. Rome, Justin W. Charton, Meera Rao, Sonja Hess, Shu-ou Shan, William M. Clemons, Jr. “ Mechanism of Assembly of a Substrate Transfer Complex during Tail-anchored Protein Targeting” (2015) Journal of Biological Chemistry Vol 290 Issue 50 pp 3006-17 https://doi.org/10.1074/jbc.M115.677328 PDBIDs 5BWK 5BW8

Kyoung-Soon Jang, Roger R. Nani, Anastasia Kalli, Sergiy Levin, Axel Müller, Sonja Hess, Sarah E. Reisman, William M. Clemons, Jr. "A cationic cysteine-hydrazide as an enrichment tool for the mass spectrometric characterization of bacterial free oligosaccharides" (2015) Analytical and Bioanalytical Chemistry Vol 407 Issue 20 pp 6181-90 doi.org/10.1007/s00216-015-8798-8

Katsuhiko Mitachi, Shajila Siricilla, Lada Klaic, William M Clemons, Michio Kurosu "Chemoenzymatic syntheses of water-soluble lipid I fluorescent probes" (2015) Tetrahedron Letters Vol 56 Issue 23 pp 3441-6 doi.org/10.1016/j.tetlet.2015.01.044

Jee Young Mock, Justin W. Charton, Ma'ayan Zaslaver, Yue Xu, Yihong Ye, William M Clemons, Jr. "Bag6 complex contains a minimal tail-anchor–targeting module and a mock BAG domaini" (2015) Proceedings of the National Academy of Sciences Vol 112 Issue 1 pp 106-11 doi.org/10.1073/pnas.1402745112 PDBID 4WWR

Axel Müller, Morgan Beeby, Alasdair W McDowall, Janet Chow, Grant J Jensen, William M Clemons, Jr. "Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni" (2014) Microbiology Open Vol 3 Issue 5 pp 702-10 doi.org/10.1002/mbo3.200

Harry B Gristick, Meera Rao, Justin W Chartron, Michael E Rome, Shu-ou Shan, William M Clemons, Jr. “Crystal structure of ATP-bound Get3–Get4–Get5 complex reveals regulation of Get3 by Get4” (2014) Nature Structural and Molecular Biology Vol 21 pp 437-42 doi.org/10.1038/nsmb.2813 PDBID 4PWX

Kyoung-Soon Jang, Michael J. Sweredoski, Robert L.J. Graham, Sonja Hess, William M. Clemons, Jr. “Comprehensive proteomic profiling of outer membrane vesicles from Campylobacter jejuni” (2014) Journal of Proteomics. Vol 98 pp 90-98 doi.org/10.1016/j.jprot.2013.12.014

Yanfen Liu, Nia Soetandyo, Jin-gu Lee, Liping Liu, Yue Xu, William M Clemons, Jr., Yihong Ye “USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation” (2014) eLife. 3:e01369 doi.org/10.7554/eLife.01369

Michael E Rome, Meera Rao, William M. Clemons, Jr., Shu-ou Shan “Precise timing of ATPase activation drives targeting of tail-anchored proteins” (2013) Proceedings of the National Academy of Sciences. Vol 110 Issue 19 pp7666-71 doi.org/10.1073/pnas.1222054110

Sureshkumar Ramasamy, Ravinder Abrol, Christian J.M. Suloway, William M. Clemons, Jr. “The Glove-like Structure of the Conserved Membrane Protein TatC Provides Insight into Signal Sequence Recognition in Twin-Arginine Translocation” (2013) Structure. Vol 21 Issue 5 pp 777-88 doi.org/10.1016/j.str.2013.03.004 PDBIDs 4HTS 4HTT

Justin W. Chartron, David G. VanderVelde, William M. Clemons, Jr. “Structures of the Sgt2/SGTA Dimerization Domain with the Get5/UBL4A UBL Domain Reveal an Interaction that Forms a Conserved Dynamic Interface” (2012) Cell Reports. Vol 2 No 6 pp 1620-32 doi.org/10.1016/j.celrep.2012.10.010 PDBIDs 4GOF 4GOE 4GOD 4GOC 2LXC 2LXB 2LXA

Shiho Tanaka, William M. Clemons, Jr. “Minimal requirements for inhibition of MraY by lysis protein E from bacteriophage ΦX174” (2012) Molecular Microbiology. Vol 85 Issue 5 pp 975-85 doi.org/10.1111/j.1365-2958.2012.08153.x

Justin W. Chartron, David G. VanderVelde, Meera Rao, William M. Clemons, Jr. “Get5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 Complex” (2012) Journal of Biological Chemistry. Vol 287 No 11 pp 8310-7 doi.org/10.1074/jbc.M111.333252 PDBIDs 3VEJ 2L00 2LNZ

Justin W. Chartron, William M. Clemons, Jr., Christian J. M. Suloway. “The complex process of GETting tail-anchored membrane proteins to the ER” (2012) Current Opinion in Structural Biology Vol 22 No 2 pp 217-24 doi.org/10.1016/j.sbi.2012.03.001

Christian J.M. Suloway, Michael E. Rome, and William M. Clemons, Jr. “Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue” (2011) EMBO Journal. Vol 31 No 3 pp 709-19 doi.org/10.1038/emboj.2011.433 PDBIDs 3UG6 3UG7

Justin W. Chartron, Grecia M. Gonzalez, William M. Clemons, Jr. “A Structural Model of the Sgt2 Protein and Its Interactions with Chaperones and the Get4/Get5 Complex” (2011) Journal of Biological Chemistry. Vol 286 No 39 pp 34325-34 doi.org/10.1074/jbc.M111.277798 PDBID 3SZ7

Justin W. Chartron, Christian J. Suloway, Ma'ayan Zaslaver, William M. Clemons, Jr. “Structural characterization of the Get4/Get5 complex and its interaction with Get3” (2010) Proceedings of the National Academy of Sciences. Vol 107 No 27 pp 12127-32 doi.org/10.1073/pnas.1006036107 PDBID 3LKU

Christian J. M. Suloway, Justin W. Chartron, Ma'ayan Zaslaver, William M. Clemons, Jr. “Model for eukaryotic tail-anchored protein binding based on the structure of Get3” (2009) Proceedings of the National Academy of Sciences. Vol 106 No 35 pp 14849-54 doi.org/10.1073/pnas.0907522106 PDBIDs 3IDQ 3IBG

Suresh Ramasamy, William Clemons, Jr. “Structure of the twin-arginine signal-binding protein DmsD from Escherichia coli” (2009) Acta Crystallographica F. Vol F65 Pt 8 pp 746-50 doi.org/10.1107/S1744309109023811 PDBID 3CWO

* indicates equal contribution